CARBA 6-Carbapenemase Rapid Test Cassette

The kit is used for in vitro qualitative detection of KPC, NDM, VIM, IMP, 0XA23, and 0XA48 carbapenemases produced by bacteria cultured from human samples to help diagnose infection. The only MULTIPLEX PHENOTYPlC test capable of detecting the 6 Phenotypes carbapenemases.

Carbapenemase-producing Organisms (CPO), and more specifically, Carbapenem resistant Enterobacteriaceae (CRE) represent a major public health concern worldwide due to their broad spectrum of resistance to antibiotics including, besides carbapenems, most classes of antimicrobial agents, and thus leaving very few options for the management of infected patients. Besides CREs, CPOs also include nonfermenting Gram-negative bacilli (NFGNB), such as Pseudomonas aeruginosa and Acinetobacter baumannii that exhibit resistance not only to beta lactam and other groups of antibiotics, but also to Carbapenems. The rapid spread of CPOs and genes encoding these resistances has led to nosocomial outbreaks and endemic situations in several countries in Europe as well as elsewhere worldwide.

Carbapenemases represent the most versatile family of β-lactamases, Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria producing these β-lactamases may cause serious infections in which the carbapenemase activity renders many β-lactams ineffective. Carbapenemases are members of the molecular class A, B, and D β-lactamases.

The class A carbapenemase group includes members of the SME, IMI, NMC, GES, and KPC families. Of these, the KPC carbapenemases are the most prevalent, found mostly on plasmids in Klebsiella pneumoniae. The class D carbapenemases consist of OXA-type β-lactamases frequently detected in Acinetobacter baumannii. The metallo-β-lactamases belong to the NDM, IMP, VIM, SPM, GIM, and SIM families and have been detected primarily in Pseudomonas aeruginosa.—PubMed Central, National Center for Biotechnology.

This type of resistance genes are already widespread in certain parts of the world, particularly Europe, Asia and South America.

Key Features:

Kit components: CARBA 6-Carbapenemase Rapid Test Cassette

Specification: 20 tests/kit

Package Insert: 1

Inoculating loop: 20

Sample extraction tube: 20

Sample extraction solution: Phosphate buffer (Containing surfactant and preservatives), 0.5mL*20 vial

Positive Control (Optional)

Advantages:

Low LoD: Lower detection limit, more specifications to choose and the testing items are complete.

KPC: 0.30 ng/mL, NDM: 0.15 ng/mL, IMP: 0.15 ng/mL,VIM: 0.30 ng/mL, OXA-48: 0.125 ng/mL, OXA-23: 0.10 ng/mL.

Sensitivity & Specificity:100%

Clear:The results are clear and easy to read.

Convenient: \The disposables for the test are all provided, such as: Inoculating loop,  extraction tube.

Stable: Easy for transportation. Stable at room temperature: 4-30℃ for 24 months.