During the first 3 days after a dengue fever infection, the immune system produces IgM antibodies to neutralize the virus.dengue ns1 igg igm This test detects the presence of these IgM antibodies in your blood sample. If the test result is negative, it means that you have not been infected or that your IgM antibodies have reverted back to normal (during early phase of infection). On the other hand, if the test result is positive, then you probably have been infected recently and that your IgG antibodies are still present in the body. This test can also be used to check for past infections as well.
The test detects antibodies to the NS1 protein of the dengue virus in your blood sample.dengue ns1 igg igm It is a rapid chromatographic immunoassay and can be performed on whole blood, serum or plasma samples. It is easy to use and the results can be interpreted within 15-20 minutes. The result can be used to aid in the diagnosis of the disease as well as follow up of patients with suspected acute or convalescent dengue fever.
Dengue is a mosquito-borne disease and spreads due to bite of infected aedes aegpti mosquito. It can lead to severe disease in some patients and even death. It is advisable to use repellents containing permethrin and DEET to protect yourself from the mosquito bite.
Turklab’s dengue ns1 igg igm is a rapid chromatographic immunoassay for the qualitative detection of NS1 antigen and IgM and IgG antibodies against dengue virus in whole blood, serum or plasma. It is intended as a screening test to aid in the diagnosis of dengue fever, a disease caused by the bite of infected aedes mosquito.
We evaluated the performance of a prototype NS1 RDT and a prototype IgM/IgG RDT in a laboratory and field evaluation during an active outbreak of dengue fever in Touba, central Senegal. During lab evaluation, we obtained high sensitivity (>82% [60-95%]) and specificity for the NS1 RDT when compared with the gold standard ELISA NS1 antibody test.
During field evaluation, we observed high sensitivity and specificity for the IgM/IgG RDT. However, IgG sensitivity was lower than expected and may be due to the low number of IgG positive samples tested during the outbreak. It is recommended that IgG sensitivity be improved for all three serotypes, particularly for DENV3 as it can be difficult to detect in Senegal. Despite the lowered IgG sensitivity, the overall diagnostic performance of the IgG/IgM RDT was satisfactory for all 3 DENV serotypes. In addition, a high serotype sensitivity was found for the NS1 RDT at all antibody levels. This is an important finding, as the availability of this type of test in Senegal is limited. The higher sensitivity of the NS1 RDT in combination with IgG/IgM allows for a more sensitive diagnosis at the patient level. This is especially true at low levels of antibody.